Yay! the topic is revived!
There are several big American mistakes, including Israel. Others include Vietnam, Guatemala, El Salvador, the overthrow of the democratic Iranian government and replacing it with the brutal Shah, who was then overthrown by Muslim fundamentalists, supporting Osama bin-Laden in Afganistan against the USSR, supporting Saddam Hussein al-Tikriti against Iran for years, and in my opinion the worst: The overthrow of the democratically elected president of Chile Salvador Allende by a military coup arranged by General Augusto Pinochet and suported by the USA Government, most visibly Kissinger.